Articles

Antimetastatic Activity of the Photodynamic Agent Hypericin in the Dark
Michael Blank1, Gad Lavie2, Mathilda Mandel2, Sadick Hazan2, Arie Orenstein3, Daniel Meruelo4 and Yona Keisari1*
1Department of Human Microbiology, Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel
2Institute of Hematology and Blood Transfusion Center, Tel-Hashomer, Israel
3Center of Advanced Technologies, Sheba Medical Center, Tel-Hashomer, Israel
4Department of Pathology, NYU Medical Center, New York, NY, USA Read More...


Enhanced Ubiquitinylation of Heat Shock Protein 90 as a Potential Mechanism for Mitotic Cell Death in Cancer Cells Induced with Hypericin
Michael Blank,1 Mathilda Mandel,2 Yona Keisari,1 Daniel Meruelo,3 and Gad Lavie2,3
1Department of Human Microbiology, Sackler Faculty of Medicine, Tel-Aviv University, Tel Aviv, Israel; 2Institute of Hematology and Blood Transfusion Center, Sheba Medical
Center, Tel-Hashomer, Israel; and 3Department of Pathology, New York University Medical Center, New York, New York Read More...

Inhibition of the CD8+ T Cell-Mediated Cytotoxicity Reaction by Hypericin: Potential for Treatment of T Cell-Mediated Diseases
Gad Lavie1,2, Daniel Meruelo2, Karin Aroyo1 and Mathilda Mandel1
1Institute of Hematology and Blood Transfusion Center, Sheba Medical Center, Tel-Hashomer, Israel
2Department of Pathology, New York University Medical Cetner, New York, NY 10016, USA Read More...

‘‘Competitive Quenching’’: A Mechanism by Which Perihydroxylated Perylenequinone Photosensitizers Can Prevent Adverse Phototoxic Damage Caused by Verteporfin During Photodynamic Therapy
Gad Lavie 1, Tilda Barliya1, Mathilda Mandel1, Michael Blank2, Yonina Ron3, Arie Orenstein4, Tami Livnat1, Noga Friedman5, Lev Weiner5, Mordechai Sheves5 and Dov Weinberger3
1Institute of Hematology & Blood Center, Sheba Medical Center, Tel-Hashomer, Israel
2Department of Molecular Genetics and Biochemistry, Tel Aviv University, Tel Aviv, Israel
3Department of Ophthalmology, Beilinson Medical Center and Tel-Aviv University School of Medicine, Tel Aviv, Israel
4Center of Advanced Technology, Sheba Medical Center, Tel-Hashomer, Israel
5Department of Organic Chemistry, The Weizmann Institute of Science, Rehovot, Israel Read More...

Photoactivated Hypericin is An Anti-Proliferative Agent That Induces a High Rate of Apoptotic Death of Normal, Transformed, and Malignant T- Lymphocytes: Implications for the Treatment of Cutaneous Lymphoproliferative and Inflammatory Disorders
Fox F., Niu, Z., Tobia, A., and Rook, A
1Department of Dermatology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
J. Investigative Dermatology,111: 327, 1998. Read More...